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成果及论文

1.ChenFX,XieP,CollingsCK,CaoK,MarshallSA,RendlemanEJ,UgarenkoM,ZhangA,ShiekhattarR,SmithER,ShiekhattarR,ZhangMQ,ShilatifardA.PAF1regulationofpromoter-proximalpausereleaseviaenhanceractivation.Science.2017Sep22;357(6357):1294-1298. 2.ChenFX,WoodfinAR,GardiniA,RickelsRA,MarshallSA,SmithER,ShiekhattarR,ShilatifardA.PAF1,amolecularregulatorofpromoter-proximalpausingbyRNApolymeraseII.Cell.2015Aug;162(5):1003-1015. 3.ChenF,GaoX,ShilatifardA.StablypausedgenesrevealedthroughinhibitionoftranscriptioninitiationbytheTFIIHinhibitortriptolide.Genes&Development.2015Jan1;29(1):39-47. 4.ChenFX,SmithER,ShilatifardA.Borntorun:ControlofRNApolymeraseIItranscriptionelongation.NatureReviewsMolecularCellBiology.2018May8.doi:10.1038/s41580-018-0010-5. 5.ChenF*,YangH*,DongZ*,FangJ,WangP,ZhuT,GongW,FangR,ShiYG,LiZ#,XuY#.StructuralinsightintosubstraterecognitionbyhistonedemethylaseLSD2/KDM1b.CellResearch.2013Feb;23(2):306. 6.FangR*,ChenF*,DongZ,HuD,BarberaAJ,ClarkEA,FangJ,YangY,MeiP,RutenbergM,LiZ,ZhangY,XuY,YangH,WangP,SimonMD,ZhouQ,LiJ,MarynickMP,LiX,LuH,KaiserUB,KingstonRE,XuY#,ShiYG#.LSD2/KDM1BanditscofactorNPAC/GLYR1endowastructuralandmolecularmodelforregulationofH3K4demethylation.MolecularCell.2013Feb7;49(3):558-70. 7.ChenFX,MarshallSA,DengY,TianjiaoS.MeasuringNascentTranscriptsbyNascent-seq.MethodsinMolecularBiology.2018;1712:19-26. 8.HuangYH,HuJ,ChenF,LecomteN,BasnetH,DavidCJ,WitkinMD,AllenPJ,LeachSD,HollmannTJ,Iacobuzio-DonahueCA,MassagueJ.ID1mediatesescapefromTGF-βtumorsuppressioninpancreaticcancer.CancerDiscovery.2019Oct3.pii:CD-19-0529.