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成果及论文

1.XuD,YangM,CapitanoM,GuoB,LiuS,WanJ,BroxmeyerHE#,HuangX#.(#corresponding)Pharmacologicalactivationofnitricoxidesignalingpromoteshumanhematopoieticstemcellhomingandengraftment.Leukemia.2020.3online. 2.HuangX#,BroxmeyerHE.(#corresponding)Progresstowardsimprovinghomingandengraftmentofhematopoieticstemcellsforclinicaltransplantation.CurrOpinHematol.2019Jul26(4):266-272. 3.HuangX*,GuoB*,LiuS,WanJ,BroxmeyerHE.(*co-equalcontribution)NeutralizingnegativeepigeneticregulationbyHDAC5enhanceshumanhematopoieticstemcellhomingandengraftment.NatureCommunications.2018Jul16;9(1):2741. 4.GuoB*,HuangX*,LeeMR,LeeSA,BroxmeyerHE.(*co-equalcontribution)AntagonizingPPARγ-FBP1axisrepressedglycolysisexpandshumanhematopoieticstemandprogenitorcells.NatureMedicine.2018Mar;24(3):360-367. 5.HuangXandBroxmeyerHE.m6AreadersuppressionbolstersHSCexpansion.CellResearch.2018Sep;28(9):875-876 6.HuangX.TrinhT,AljoufiA,BroxmeyerHE.Hypoxiasignalingpathwayinstemcellregulation:goodandevil.CurrStemCellReports.2018Jun.4(2):149-157. 7.HuangX,LeeMR,CooperS,HangocG,HongKS,ChungHMandBroxmeyerHE.ActivationofOCT4enhancesexvivoexpansionofhumancordbloodhematopoieticstemandprogenitorcellsbyregulatingHOXB4expression.Leukemia,2016Jan;30(1):144-153. 8.GuoB*,HuangX*,ZhangP,QiL,LiangQ,ZhangX,HuangJ,FangB,HouW,HanJ,ZhangH.(*co-equalcontribution)Genome-widescreenidentifiessignalingpathwaysthatregulateautophagyduringC.elegansdevelopment.EMBORep.2014June;15(6):705-713. 9.HuangX,ZhangH,ZhangH.Theautosomalsignalelementsea-2regulateslarvaldevelopmentaltimingandadultlifespaninC.elegans.Development.2011May;138(10):2059-2068. 10.HuangX,TianE,XuY,ZhangH.TheC.elegansengrailedhomologceh-16regulatestheself-renewalexpansiondivisionofstemcell-likeseamcells.DevBiol.2009Sep15;333(2):337-347. 11.CapitanoML,Mor-VakninN,SahaAK,CooperS,LegendreM,GuoH,Contreras-GalindoR,KappesF,SartorMA,LeeCT,HuangX,MarkovitzDM,BroxmeyerHE.SecretednuclearproteinDEKregulateshematopoiesisthroughCXCR2signaling.JClinInvest.2019May20;130. 12.CapitanoM,ZhaoL,CooperS,ThorsheimC,SuzukiA,HuangX,DentAL,MarksMS,AbramsCS,BroxmeyerHE.PhosphatidylinositoltransferproteinsregulatemegakaryocyteTGF-β1secretionandhematopoiesisinmice.Blood.2018Sep6;132(10):1027-1038. 13.GuoB,HuangX,CooperS,BroxmeyerHE.Glucocorticoidhormone-inducedchromatinremodelingenhanceshumanhematopoieticstemcellhomingandengraftment.NatureMedicine.2017Apr;23(4):424-428. 14.MantelCR,O'LearyHA,ChittetiBR,HuangX,CooperS,HangocG,BrustovetskyN,SrourEF,LeeMR,Messina-GrahamS,HaasDM,FalahN,KapurR,PelusLM,BardeesyN,FitamantJ,IvanM,KimKS,BroxmeyerHE.Enhancinghematopoieticstemcelltransplantationefficacybymitigatingoxygenshock.Cell.2015Jun161(7):1553-1565